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Fahr's disease: bilateral symmetrical striopallidodentate calcification in two brothers with two distinct presentations
  1. Abdalla Bowirrat1,
  2. Mustafa Yassin2,
  3. Faozi Artoul3,
  4. Suheil Artul4
  1. 1Department of Neuroscience, EMMS Nazareth Hospital, Nazareth, Israel
  2. 2Department of Orthopeadic, Rabin Medical Center, Tel-aviv, Israel
  3. 3Department of Nuclear Medicine, Meir Hospital, Kfar Saba, Israel
  4. 4Department of Radiology, EMMS Nazareth Hospital, Nazareth, Israel
  1. Correspondence to Professor Bowirrat Abdalla, Prof.Bowirrat{at}


Bilateral striopallidodentate calcinosis, commonly known as Fahr's disease is a rare clinical entity present mainly with extrapyramidal signs and accompanied with metabolic, biochemical, neuroradiological and neuropsychiatric situations. It is characterised by the symmetrical and bilateral intracranial deposition of calcium associated with cell loss in the basal ganglia, cerebral cortex and cerebellum.In this study, we discussed two brothers’ cases of Fahr's diseases who presented with different symptomatology. The first presented with walking difficulty, cramps and dysarthria and moderate memory impairment whereas the second with vertigo, ataxia, forgetfulness and headache. CT scans of both patients revealed intracranial diffuse bilateral calcifications in the basal ganglia and the cerebellum. The second patient revealed progressive cerebral atrophy but reduction in the calcification.Fahr's disease, although encountered rarely, should also be taken into account in the differential diagnosis of cases with abnormal intracranial calcifications along with other familial, congenital and metabolic diseases and syndromes.

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