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Acrodermatitis enteropathica-like skin lesions in a neonate
  1. Kamal Arora1,
  2. Rashmi Ranjan Das2,
  3. Shasanka Shekhar Panda3,
  4. Madhulika Kabra4
  1. 1Department of Pediatrics, Dayanand Medical College, Ludhiana, Punjab, India
  2. 2Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India
  3. 3Department of Pediatrics Surgery, All India Institute of Medical Sciences (AIIMS), New Delhi, India
  4. 4Department of Pediatrics Genetics, All India Institute of Medical Sciences (AIIMS), New Delhi, India
  1. Correspondence to Dr Shasanka Shekhar Panda; drshasankaiims06{at}


A male neonate was born to a sixth-gravida mother with a history of four early-neonatal deaths. On day 21 of life, the patient was admitted for poor feeding, vomiting and encephalopathy. Final diagnosis of propionic acidaemica (propionylcarnitine, 17.67 μmol/L) was made. He was managed by peritoneal dialysis followed by protein-free and special lipid diet, sodium benzoate and multivitamins. On day 28 of life, he developed acrodermatitis enteropathica-like skin lesions on perioral and diaper area that did not respond to oral zinc or antimicrobials. A possibility of acrodermatitis acidaemica was kept and supplementation with essential amino acids started, following which the skin lesions regressed.

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