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A novel subtype of myeloproliferative disorder? JAK2V617F-associated hypereosinophilia with hepatic venous thrombosis
  1. Sowjanya Dasari1,
  2. Kushal Naha1,
  3. Manjunath Hande1,
  4. G Vivek2
  1. 1Department of Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India
  2. 2Department of Cardiology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India
  1. Correspondence to Dr G Vivek, vivekgraman{at}


We report the case of a 27-year-old man, presenting with one episode of massive haematemesis and a history of persistent eosinophilia for the past 8 months. An evaluation revealed hepatic cirrhosis with portal hypertension, secondary to chronic Budd-Chiari syndrome. Further investigations confirmed a diagnosis of hypereosinophilic syndrome. Molecular genetic analysis was negative for FIP1L1-PDGFRA gene rearrangement, but positive for JAK2V617F mutation.

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