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The development of peripheral T-cell lymphoma after successful treatment for diffuse large B-cell lymphoma in a patient with suspected adult onset immunodeficiency: more questions than answers?
  1. Mari Frances Kilner1,
  2. Serena Merante2,
  3. Alexandr Svec3
  1. 1Department of Haematology, Newcastle upon Tyne Hospitals Trust, Newcastle upon Tyne, UK
  2. 2Department of Haematology, James Cook University Hospital, Middlesbrough, UK
  3. 3Department of Pathology, James Cook University Hospital, Middlesbrough, UK
  1. Correspondence to Dr Mari Frances Kilner, marikilner{at}


We present the case of a 60-year-old woman who developed peripheral T-cell lymphoma following successful treatment for high-grade B-cell non-Hodgkin's lymphoma. We consider the possible aetiology of this unusual occurrence. We hypothesise that this case represents one of the undiagnosed adult-onset immunodeficiency, in which the pathogenesis of the patient's T-cell lymphoma may have been in part iatrogenic, namely related to previous immunotherapy with rituximab. We feel this case highlights the importance of rebiopsy in patients with recurrent lymphadenopathy and a history of haematological malignancy and hence acts as an important aide memoir in the investigation of such cases.

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