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Unilateral proptosis: an unusual presentation of prostatic carcinoma
  1. Anna Louise Pouncey1,
  2. Thomas Peter Fox2,
  3. Catherine Anne Bryant3
  1. 1Oxford University, Oxford, UK
  2. 2Department of Orthopaedic, King's College Hospital NHS Foundation Trust, London, UK
  3. 3Department of Clinical Gerontology, King's College Hospital NHS Foundation Trust, London, UK
  1. Correspondence to Dr Thomas Peter Fox, t.fox1{at}


A 68-year-old man presented acutely with periorbital pain and proptosis of the right eye, on a background of generalised pain and weight loss. Imaging showed bilateral signal abnormalities in the basal skull extending into the extraconal orbits with compression of the right optic nerve. His medical history revealed symptoms in keeping with benign prostatic hypertrophy. However, the prostate was irregular on rectal examination and prostate-specific antigen was markedly raised at 1880 ng/dl. A provisional diagnosis of metastatic prostatic carcinoma was made based on the clinical and radiological picture. This was later confirmed to be metastatic adenocarcinoma through means of tissue diagnosis.

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