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Salvage immunotherapy for fulminant pseudomembranous colitis
  1. Salman Abdulaziz1,
  2. Nabil Abou-Shala1,
  3. Ashraf Al-Tarifi1,
  4. Rashid Amin2
  1. 1Department of Adult Critical Care Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
  2. 2Formulary Management Committee, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
  1. Correspondence to Dr Salman Abdulaziz, dr-salman{at}hotmail.com

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A 49-year-old man was admitted to the intensive care unit (ICU) for septic shock secondary to Clostridium difficile infection (CDI) complicated with severe pseudomembranous colitis. His medical history was remarkable for glossectomy, proximal esophagectomy and gastric pull-up for recurrent laryngeal cancer. Two weeks prior to his ICU admission, he was treated with a 10-day course of intravenous ceftazidime for line-related sepsis, after which he had several bouts of green watery diarrhoea. CDI was confirmed by positive stool cytotoxin A immunoassay, with persistent diarrhoea despite 21 days of oral metronidazole. The …

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