Article Text

Download PDFPDF

Malignant aetiology for breathlessness, concealed by a perception of ‘exam-anxiety’
  1. Swaroop Revannasiddaiah1,
  2. Muninder K Negi2,
  3. Sridhar Papaiah Susheela1,
  4. Manoj Kumar Gupta3
  1. 1Department of Radiation Oncology, HealthCare Global-Bangalore Institute of Oncology, Bengaluru, Karnataka, India
  2. 2Department of Radiotherapy, Dr Rajendra Prasad Government Medical College, Tanda, Himachal Pradesh, India
  3. 3Department of Radiotherapy & Oncology, Regional Cancer Centre, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
  1. Correspondence to Dr Swaroop Revannasiddaiah, swarooptheone{at}

Statistics from


A 14-year-old boy student who had his annual exams (academic examinations) approaching, suffered a documented history of generalised anxiety disorder, which would occasionally exacerbate during periods of perceived stress, such as with exams. Prior to previous exams, he had for many years reported of having faced a temporary cluster of symptoms comprising palpitations, insomnia and breathlessness.

Just two months prior to his most recent exams, he reported to have felt the same symptom-cluster again, including breathlessness. Without any medical consultation, he attributed his symptoms to one of ‘his usual anxiety attacks’. Moreover, the student lived away from his family, and he never discussed his symptoms with his family.

However, a week prior to his exams, he was brought to the emergency department complaining of being unable to breathe or to swallow. Evaluation with imaging promptly identified the cause for his current symptoms—a large mediastinal mass (figure 1), which was subsequently diagnosed to be a diffuse-large B-cell lymphoma.

Figure 1

CT reconstruction of a coronal section across the mid-axillary area depicting the mass (blue arrow) involving the mediastinum and the right hemithorax.

The mass (measuring 1365 cc in volume) had significantly reduced the volume of the right lung (to about 740 cc; figure 2), and also seemed to occupy some space in the left hemithorax too. There was also obvious evidence of mechanical compression of the trachea (figure 3).

Figure 2

Volumetric reconstruction (A) depicting the large size of the mediastinal mass (red), in relation to the heart (green) and the lungs. The extent of lung-volume reduction owing to the compression by the mass has been demonstrated by rendering the mass invisible (B).

Figure 3

Volumetric reconstruction depicting the marked compression of the right bronchus (orange arrow) by the mass (red volume). In comparison, the left bronchus (blue arrow) is seen to be uncompressed and hence of normal calibre. The pink volume represents the heart, and the cyan volumes represents the lungs.

This case illustrates the necessity for adequate clinical suspicion towards alternate diagnoses, even in situations wherein a previous diagnosis seems adequate enough to explain the current symptom complex. While anxiety is known to induce symptoms such as dyspnoea, it is also a well-known fact that a mass in the mediastinum too can cause the same.1 ,2

Learning points

  • It is important to look for alternate diagnoses even if a previous diagnosis seems adequate as an explanation for the symptoms.

  • Lymphomas are one of the most rapidly growing malignancies, with a rapid progression within a period of weeks being quite common.3


View Abstract


  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.