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Leflunomide-induced chronic cough in a rheumatoid arthritis patient with pulmonary tuberculosis
  1. S K Verma,
  2. Ashwini Kumar Mishra,
  3. Ashish Kumar Jaiswal
  1. Department of Pulmonary Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
  1. Correspondence to Professor S K Verma, drskverma{at}


A 40-year-old lady presented with clinicoradiological features suggestive of pulmonary tuberculosis, which was confirmed on sputum smear examination, and was started on four-drug antitubercular treatment. On subsequent visits, she complained of persistent cough, despite improvement in other symptoms. A careful anamnesis revealed that the patient had been taking leflunomide for rheumatoid arthritis for the last 10 years, and this was suspected to be the cause of the cough. The patient became asymptomatic upon stopping the drug, thereby confirming the hypothesis.

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