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A new biological approach to guided bone and tissue regeneration
  1. Marco Montanari1,
  2. Michele Callea2,
  3. Izzet Yavuz3,
  4. Michele Maglione4
  1. 1Unit of Dentistry for Special Care, Department of Oral Science, University of Bologna, Bologna, Italy
  2. 2Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”, Trieste, Italy
  3. 3Department of Pediatric Dentistry, Dicle University Faculty of Dentistry, 21280 Diyarbakır, Turkey
  4. 4Unit of Oral Surgery, Department of Medical and Surgical Science, Dental School, University of Trieste, Trieste, Italy
  1. Correspondence to Dr Michele Callea, Department of Pediatric Stomatology, Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”- Trieste, Italy; mcallea{at}


The purpose of this study was to determine the potential of platelet-rich fibrin (PRF) membranes used for guided bone and tissue regeneration. A patient with insufficient alveolar ridge width in aesthetic zone was enrolled. The patient's blood was centrifuged to obtain PRF membranes. Autogenous bone graft was mixed with bovine hydroxyapatite, PRF particles and applied to fill the defect. Five PRF membranes were placed over the bone mix. After 4 months a cone-beam CT was performed to evaluate bone regeneration. The use of PRF as cover membrane permitted a rapid epithelisation and represented an effective barrier versus epithelial cell penetration. After 4 months the site appeared precociously healed and the bone volume increased. This new approach represents a predictable method of augmenting deficient alveolar ridges. Guided bone regeneration with PRF showed limitation compared with guided bone regeneration using collagen membrane in terms of bone gain. The association of collagen membrane and PRF could be a good association.

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