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Transient improvement of poststroke apathy with zolpidem: a single-case, placebo-controlled double-blind study
  1. Katell Autret1,
  2. Annabelle Arnould2,
  3. Sarah Mathieu3,
  4. Philippe Azouvi2
  1. 1Department of PM&R, Pole St Helier, Rennes, France
  2. 2Department of PM&R, Hopital Raymond Poincaré and Université de Versailles-Saint Quentin, Garches, France
  3. 3Department of PM&R, Hopital Rotschild, Paris, France
  1. Correspondence to Professor Philippe Azouvi, philippe.azouvi{at}


We report the case of a 44-year-old patient with severe and disabling apathy nearly 2 years after a right hemisphere haemorrhagic stroke. The effect of a single dose of zolpidem was tested over a 2-week period, in alternation with either no treatment or a placebo in a double-blind randomised trial. Zolpidem was associated with a dramatic improvement in apathy, as assessed with the Apathy Inventory and the Behavioral Dysexecutive Syndrome Inventory. No adverse effect occurred during the trial.

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