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Case report
The effect of high-intensity aerobic interval training on postinfarction left ventricular remodelling
  1. Richard Godfrey1,
  2. Thomas Theologou2,3,4,
  3. Santo Dellegrottaglie5,
  4. Sukumaran Binukrishnan2,
  5. Jay Wright3,
  6. Gregory Whyte6,
  7. Georgina Ellison3,4,6
  1. 1Centre for Sports Medicine and Human Performance, School of Sport and Education, Brunel University, Uxbridge, UK
  2. 2Department of Cardiology and Radiology, The Liverpool Heart and Chest Hospital, Liverpool, UK
  3. 3Institute of Cardiovascular Medicine and Science, The Liverpool Heart & Chest Hospital, Thomas Drive, Liverpool, UK
  4. 4Stem Cell & Regenerative Biology Unit (BioStem), Research Institute for Sport & Exercise Sciences, Liverpool John Moores University, Liverpool, UK
  5. 5Division of Cardiology, Ospedale Medico-Chirurgico Accreditato Villa dei Fiori, Naples, Italy
  6. 6Cardiovascular Physiology Unit, Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
  1. Correspondence to Dr Richard Godfrey, richard.godfrey{at}


This is the third in a series of case studies on an individual with normal coronaries who sustained an idiopathic acute myocardial infarction . Bilateral pulmonary emboli almost 2 years post-myocardial infarction (MI) revealed coagulopathy as the cause. The original MI resulted in 16% myocardial scar tissue. An increasing number of patients are surviving MI, hence the burden for healthcare often shifts to heart failure. Accumulating evidence suggests high-intensity aerobic interval exercise (AHIT) is efficacious in improving cardiac function in health and disease. However, its impact on MI scar has never been assessed. Accordingly, the 50-year-old subject of this case study undertook 60 weeks of regular AHIT. Successive cardiac MRI results demonstrate, for the first time, a decrease in MI scar with exercise and, alongside mounting evidence of high efficacy and low risk, suggests AHIT may be increasingly important in future prevention and reversing of disease and or amelioration of symptoms.

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