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Unusual presentation of more common disease/injury
Isolated anaemia as a manifestation of Rh isoimmunisation
  1. Juliana Roda1,
  2. Gabriela Mimoso1,
  3. Manuela Benedito2,
  4. Dolores Faria Pereira1
  1. 1Neonatal Intensive Care Unit, Maternidade Bissaya Barreto-CHC, Coimbra, Portugal
  2. 2Haematology Department, Hospital Pediatrico de Coimbra-CHC, Coimbra, Portugal
  1. Correspondence to Dr Juliana Roda, juroda{at}


Rh isoimmunisation leads to haemolytic anaemia and hyperbilirubinaemia in the first h of life. Isolated early onset neonatal anaemia has rarely been reported. The authors describe the case of a term infant, born to an ‘A’ negative, second gravida mother. On the second day of life, pallor was noticed. His haemoglobin (Hb) was 6.8 g/dl, he had reticulocytosis and a positive direct antiglobulin test. However, he did not have a high total serum bilirubin (TSB) (87.2 μmol/l). He was transfused with red blood cells and kept under phototherapy for 3 days. Three weeks later, he received another transfusion for severe anaemia (Hb 6 5 g/dl). During this period, he was never jaundiced and the maximum level of TSB was 122 μmol/l. On follow-up, his Hb stabilised and he had no further problems. This report highlights the possibility of early onset anaemia without jaundice as the sole manifestation of Rh isoimmunisation.

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  • Competing interests None.

  • Patient consent Obtained.

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