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Rare disease
Sepsis, meningitis and cerebral abscesses caused by Citrobacter koseri
  1. Clara Vaz Marecos1,
  2. Marta Ferreira2,
  3. Maria Manuela Ferreira2,
  4. Maria Rosalina Barroso2
  1. 1Paediatric Department, Professor Doutor Fernando Fonseca Hospital, EPE, Lisbon, Portugal
  2. 2Neonatal Intensive Care Unit, Professor Doutor Fernando Fonseca Hospital, Amadora, Portugal
  1. Correspondence to Dr Clara Vaz Marecos, claravazmarecos{at}gmail.com

Summary

After a 36-week diamniotic dichorionic gestation, an infant was delivered by elective caesarean section due to growth restriction and altered diastolic flow in the umbilical artery. Birth weight was 2140 g. The patient was admitted for exclusive parenteral nutrition, with umbilical venous catheter placement. Sinus tachycardia and temperature instability with positive inflammatory markers occurred at 51 h. Penicillin and gentamicin were started, but 6 h later septic shock with disseminated intravascular coagulation was noted. Vancomycin and meropenem were started and penicillin suspended. Citrobacter koseri was isolated from blood culture. Generalised clonic convulsions occurred on day 4, and an electroencephalogram revealed severe encephalic dysfunction. Cerebrospinal fluid cytochemical analysis was suggestive of meningitis, although culture was negative. Cefotaxime was added to the drug regimen. Cranioencephalic MR showed a temporal abscess and diffuse hemispheric destruction, with no indications for neurosurgery. After 6 weeks of therapy, neuroimaging follow-up showed multiloculated cystic encephalomalacia. Currently, the patient is 14 months old with axial hypotonia and decreased movements. The source of infection has not been determined. Nosocomial infection cannot be excluded and vertical transmission is unlikely.

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Footnotes

  • Competing interests None.

  • Patient consent Obtained.

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