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Unusual association of diseases/symptoms
Cluster of neurological manifestations of rotavirus infection in children
  1. Thomas George Day1,
  2. Charlotte Jackson2,
  3. Penelope Ann Bryant3
  1. 1Paediatrics Department, Barnet and Chase Farm Hospitals NHS Trust, London, UK
  2. 2Paediatrics Department, St George’s Healthcare NHS Trust, London, UK
  3. 3Paediatric Infectious Diseases Department, St George’s Hospital, London, UK
  1. Correspondence to Dr Penelope Ann Bryant, penelope.bryant{at}


Rotavirus infection in children in the resource-rich countries is usually benign but complications are reported rarely. Four children presented within 4 weeks with neurological symptoms and stool virology positive for rotavirus. All four made a quick recovery and were discharged home after a few days without medication. At 6 weeks all were well, with no further neurological episodes. This is the first reported cluster of this nature. Potential mechanisms for how rotavirus causes its rare neurological complications are briefly discussed, along with clinical implications for clinicians managing such patients.

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  • Competing interests None.

  • Patient consent Obtained.

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