Article Text

Download PDFPDF
Unusual association of diseases/symptoms
The posterior reversible encephalopathy syndrome in HIV infection
  1. Sam Nightingale1,
  2. Chris Wood2,
  3. Jonathan Ainsworth2
  1. 1Institute of Infection and Global Health, University of Liverpool, Liverpool, UK
  2. 2HIV, North Middlesex University Hospital, London, UK
  1. Correspondence to Dr Sam Nightingale, s.nightingale{at}


Posterior reversible encephalopathy syndrome (PRES) is often associated with hypertension, however recent advances in the understanding of this condition have shown that endothelial dysfunction is responsible for much of the pathogenesis and the condition can occur in the absence of hypertension. This case describes a 32-year-old lady with untreated HIV infection who developed PRES at a normal blood pressure and without opportunistic infection or other conditions known to precipitate PRES. HIV, particularly when untreated, is associated with endothelial dysfunction and this may have been sufficient to cause PRES in this patient. To our knowledge this is the first case to describe PRES in HIV without uncontrolled hypertension, sepsis or other precipitating cause.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests None.

  • Patient consent Obtained.