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Rare disease
Breast angiosarcoma secondary to phyllodes tumour
  1. Sílvia Costa,
  2. Susana Alexandra Rodrigues Graça,
  3. António Ferreira,
  4. Jorge Maciel
  1. Department of General Surgery, Centro Hospitalar Gaia/Espinho, EPE, Gaia, Portugal
  1. Correspondence to Dr Sílvia Costa, sisse.costa{at}


Angiosarcomas are rare malignant tumours that arise from endothelial cells lining vascular channels, representing 0.04% of malignant neoplasms of the breast. Breast angiosarcomas (BAs) were first described by Schmidt in 1887, and may be primary or secondary to the pre-existing conditions. Primary BAs are more common in young women and present as a palpable mass. Secondary BAs arise in older patients, frequently 5–6 years after radiotherapy, and present as a rash.The authors describe the case of an 83-year-old woman with no history of thoracic radiotherapy or surgery. She had been observed for a breast nodule where biopsy revealed phyllodes tumour. The patient refused surgery and returned 2 years later because of an impressive increase in tumour volume and skin ulceration. She underwent mastectomy with local skin flaps. Histopathological result revealed high-grade angiosarcoma of 15×12 cm. There was follow-up without evidence of recurrence, after radiotherapy.

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