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Novel treatment (new drug/intervention; established drug/procedure in new situation)
Tianeptine in combination with monoamine oxidase inhibitors for major depressive disorder
  1. Edward H Tobe1,2,3
  1. 1Department of Psychiatry, Cooper Medical School of Rowan University, New Jersey, USA
  2. 2Department of Psychiatry, University of Medicine and Dentistry New Jersey, New Jersey, USA
  3. 3Department of Psychiatry, School of Osteopathic Medicine and Robert Wood Johnson Medical School, New Jersey, USA
  1. Correspondence to Dr Edward Tobe, edward.tobe{at}


Major depressive disorder may respond to monotherapy with monoamine oxidase inhibitors (MAOIs) or tianeptine. Literature search showed no reports of MAOIs combined with tianeptine. The method included was clinical case history.  A 59-year-old woman had partial improvement of depression with the MAOI tranylcypromine combined with topiramate, trazodone and ziprasidone. The patient had further improvement of depression symptoms after addition of tianeptine. No adverse events were evident. The combination of MAIOs and tianeptine may be effective for refractory major depressive disorder.

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