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Novel treatment (new drug/intervention; established drug/procedure in new situation)
Intravitreal dobesilate in the treatment of choroidal neovascularisation associated with age-related macular degeneration: report of two cases
  1. Pedro Cuevas1,
  2. Luis Outeiriño2,
  3. Carlos Azanza2,
  4. Guillermo Giménez-Gallego3
  1. 1Departamento de Investigación, IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain
  2. 2Department of Ophthalmology, Hospital de Día Pío XII, Madrid, Spain
  3. 3Departamento de Estructura y Función de Proteínas, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain
  1. Correspondence to Professor Pedro Cuevas, pedro.cuevas{at}


This case report presents the effectiveness of intravitreal administration of dobesilate, a synthetic fibroblast growth factor inhibitor, in two patients showing neovascular age-related macular degeneration of the classic, and of the occult choroidal neovascularisation types, respectively. Our study demonstrates that the treatment induces the regression of both forms of this pathology, as assessed by spectral optical coherence tomography. Improvement of the lesions was accompanied of visual acuity improvement.

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