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Rare disease
Acquired-transient factor X deficiency in a teenager with extensive burns
  1. Andreia Mascarenhas1,
  2. Marilene Eusébio2,
  3. Orquídea Freitas3,
  4. Teresa Almeida3
  1. 1Department of General Pediatrics, Hospital Dona Estefânia, Rua Jacinta Marta, Lisboa, Portugal
  2. 2Department of General Pediatrics, Centro Hospitalar do Barlavento Algarvio Sítio do Poço Seco, Portimão, Portugal
  3. 3Hematology Unit, Hospital Dona Estefânia, Rua Jacinta Marta, Lisboa, Portugal
  1. Correspondence to Dr Andreia Mascarenhas, amascarenhas22{at}


Acquired factor X deficiency is an extremely rare situation. It has shown to be associated with systemic amyloidosis, respiratory mycoplasma infection, factor X inhibitors, antiphospholipid antibodies, vitamin K deficiency/liver disease as well as the use of certain medications (meropenem, valproic acid). The pathogenesis and transient nature of this deficit remain poorly understood. The authors describe the case of a teenager hospitalised for extensive burns that developed active bleeding after removal of central venous catheter. He was diagnosed with transient factor X deficiency. Normalisation of coagulation status and factor X levels occurred spontaneously 10 days after the bleeding episode.

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  • Competing interests None.

  • Patient consent Obtained.