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Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
Complete AV-block secondary to lithium-clozapine therapy and relapsing multiple sclerosis in a bipolar patient
  1. Edward EE Gabeler,
  2. Addy JM van Miltenburg
  1. Cardiology Department, Sint Franciscus Gasthuis, Rotterdam, Netherlands
  1. Correspondence to Dr Edward EE Gabeler, eeegabeler{at}hotmail.com

Summary

A complete atrioventricular block (CAVB) can be a lethal complication when it is not treated directly with isoprenaline and pacemaker therapy. The overall incidence of CAVB varies between 4 to 8 per cent with a mortality OR of 3.2 within 30 days if untreated. Main causes of CAVB are inferior myocardial infarction, congenital AV node malformation, mitral valve insufficiency and valve surgery, metabolic disorders and intoxications. The authors describe a case with a CAVB due to lithium-clozapine therapy and relapsing multiple sclerosis.

https://doi.org/10.1136/bcr.10.2011.5030

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    Footnotes

    • Competing interests None.

    • Patient consent Obtained.