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Unusual association of diseases/symptoms
Gliadin allergy manifested with chronic urticaria, headache and amenorrhea
  1. Ervin Ç Mingomataj1,
  2. Enkelejda Gjata2,
  3. Alketa Bakiri3,
  4. Fatmira Xhixha4,
  5. Entela Hyso5,
  6. Alkerta Ibranji1
  1. 1Department of Allergology and Clinical Immunology, Mother Theresa School of Medicine, Tirana, Albania
  2. 2Department of Internal Medicine, District Hospital of Lushnja, Lushnja, Albania
  3. 3Department of Preclinical Disciplines, Albanian University, Medical University, Tirana, Albania
  4. 4Department of Internal Medicine, Specialties Policlinic No 3, Tirana, Albania
  5. 5Department of Internal Medicine, Regional Hospital, Vlora, Albania
  1. Correspondence to Mr Ervin Ç Mingomataj, allergology{at}


Gluten intolerance is an autoimmune enteropathy caused by heterogeneous mixture of wheat storage proteins. Malabsorption symptoms imply diarrhoea, abdominal pain/bloating and weight loss. This case describes a 22-year-old female subject, who had chronic headache, joint pain, urticaria and long period of amenorrhea. Skin prick tests revealed a sensitisation to α-gliadin, while neurological, gynaecological, endocrine and clinical-laboratory examinations did not justify the above-mentioned symptoms. Gluten-free diet resolved chronic symptoms and re-established the menstrual cycle, whereas a temporary gliadin daily diet re-exacerbated all clinical symptoms. Urticaria occurred 20 min and the chronic headache the next day after exposure to the gliadin-rich diet. In addition, the missing of the expected menstrual bleeding was observed. This case demonstrates that gliadin intake can induce malabsorption and ‘idiopathic’ neuronal or gynaecological symptoms.

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  • Competing interests None.

  • Patient consent Obtained.

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