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Unusual association of diseases/symptoms
Simultaneously developed polymyositis and autoimmune hepatitis
  1. Hiroyuki Hounoki1,
  2. Koichiro Shinoda1,
  3. Reina Ogawa1,
  4. Hirofumi Taki1,
  5. Koichi Tsuneyama2,
  6. Kazuyuki Tobe1
  1. 1First Department of Internal Medicine, University of Toyama, Toyama, Japan
  2. 2Department of Diagnostic Pathology, University of Toyama, Toyama, Japan
  1. Correspondence to Dr Hirofumi Taki, htaki-tym{at}


The inflammatory myopaties such as polymyositis (PM) and dermatomyositis (DM) are autoimmune inflammatory muscle disorders characterised by the development of proximal and often symmetrical muscle weakness. Levels of serum muscle enzymes such as creatine kinase (CK), lactate dehydrogenase (LDH), asparate aminotransferase (AST) and alanine aminotransferase (ALT) are usually elevated. However, high levels of AST, ALT and LDH, without a determination of CK, are often misdiagnosed with hepatic diseases. Conversely, concomitant elevations of AST, ALT and LDH along with CK in patients with PM and DM may be considered to be due to myopathy itself even in a case of coexistence of liver injury. Oral administration of prednisolone was begun at a dose of 60 mg/day, resulting in a good outcome.

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  • Competing interests None.

  • Patient consent Obtained.

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