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Unusual association of diseases/symptoms
Lhermitte-Duclos and Cowden diseases: breast cancer as an unusual initial presentation of these overlapping conditions
  1. Siun Walsh1,
  2. Michael Carter2,
  3. Niall Tubridy2,
  4. Enda W McDermott1
  1. 1Department of Surgery, St Vincent’s University Hospital, Dublin, Ireland
  2. 2Department of Neurology, St Vincent’s University Hospital, Dublin, Ireland
  1. Correspondence to Miss Siun Walsh, siunwalsh{at}


The authors report the case of a woman presenting with breast cancer who subsequently developed neck pain and ataxia. She had a family history of breast cancer and Cowden disease. A MRI study of the brain revealed a lesion in the cerebellum consistent with Lhermitte-Duclos disease (LDD) and a lesion consistent with a meningioma in the temporal lobe. This case emphasises the importance of awareness of the overlap between LDD and Cowden disease.

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  • Competing interests None.

  • Patient consent Obtained.

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