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Learning from errors
Statin resistant dyslipidemia in a patient treated with amiodarone
  1. Ahmad Al-Sarraf1,2,
  2. Min Li2,
  3. Jiri Frohlich1,2
  1. 1Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
  2. 2Healthy Heart Program, St Paul’s Hospital, Vancouver, British Columbia, Canada
  1. Correspondence to Professor Jiri Frohlich, jifr{at}mail.ubc.ca

Summary

The authors describe a patient treated with amiodarone presented with high low-density lipoprotein cholesterol (LDL-C) levels who did not respond to treatment with a statin. Both amiodarone and amiodarone induced hypothyroidism influence the synthesis of LDL-receptor which may explain the lack of effect of statin. This was confirmed by normalisation of LDL-C upon discontinuation of amiodarone and treatment with thyroxine.

http://dx.doi.org/10.1136/bcr.08.2011.4620

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    Footnotes

    • Competing interests None.

    • Patient consent Obtained.