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Unexpected outcome (positive or negative) including adverse drug reactions
Diffuse alveolar haemorrhage may be associated with intravitreal injection of bevacizumab in a patient with systemic risk factors
  1. Ruriko Seto,
  2. Hideto Yamada,
  3. Hiroshi Wada,
  4. Makoto Osawa,
  5. Taishi Nagao,
  6. Yasutaka Nakano
  1. Division of Respiratory Medicine, Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
  1. Correspondence to Hideto Yamada, otedih{at}


The authors present a rare case where acute respiratory failure occurred after the intravitreal bevacizumab injection for a branch retinal vein occlusion. Chest CT scan showed ground-glass opacity in the bilateral lung fields. The finding of bronchoalveolar lavage fluid revealed alveolar haemorrhage. Corticosteroid therapy resulted in a rapid improvement of respiratory failure. This report suggests that intravitreal injection of bevacizumab may be associated with diffuse alveolar haemorrhage and acute lung injury.

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  • Competing interests None.

  • Patient consent Obtained.

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