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Novel treatment (new drug/intervention; established drug/procedure in new situation)
Successful treatment of acute mania and perineal abscess using dexmedetomidine sedation as adjunctive therapy
  1. Adam L. Ackerman1,
  2. Cristin Mount2
  1. 1Department of Medicine, Keesler Air Force Hospital, Keesler AFB, Mississippi, United States
  2. 2Department of Medicine, Madigan Army Medical Center, Tacoma, Washington, United States
  1. Correspondence to Dr Cristin Mount, cristin.mount{at}


Acute psychiatric illness with agitation presents the clinician with a dangerous, potentially life-threatening situation often requiring complex management. Alteration in patients’ insight and judgment may result in medication non-compliance, potentially further complicating therapy directed at the primary psychiatric illness as well as any co-existing conditions. Sedation is often necessary to control dangerous behaviour during the period of antipsychotic and mood-stabilising drug titration. Dexmedetomidine is a centrally acting selective α2-adrenergic agonist with anaesthetic and sedative properties widely used in intensive care units for sedation in critically ill patients. The authors report the case of a patient managed successfully with dexmedetomidine sedation while being treated for acute mania and perineal abscess.

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  • Competing interests None.

  • Patient consent Not obtained.

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