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Novel treatment (new drug/intervention; established drug/procedure in new situation)
Novel approach to treatment of rectal mucosa-associated lymphoid tissue lymphoma
  1. Neetu Chahil1,
  2. Peter Bloom2,
  3. Jeremiah Tyson1,
  4. Saad Jazwari1,
  5. James Robilotti2,
  6. Nicholas Gaultieri2
  1. 1Medicine, St Vincent Catholic Medical Center, New York, USA
  2. 2Gastroenterology, St Vincent Catholic Medical Center, New York, USA
  1. Correspondence to Jeremiah Tyson, hardstylzmd{at}


A 78-year-old Hispanic woman with a medical history of osteoporosis, hyperlipidaemia and dyspepsia presented to a gastrointestinal clinic complaining of a small amount of rectal bleeding following bowel movements for 6 months. Colonoscopy demonstrated a 3×3 cm submucosal rectal mass. Pathological analysis revealed ulcerated colonic mucosa with diffuse proliferation suggestive of a lymphoproliferative process. Immunohistochemistry and flow cytometry of the specimen supported a diagnosis of mucosa-associated lymphoid tissue lymphoma. The patient was treated with amoxicillin, clarithromycin and lansoprazole for 2 weeks. A C-14 urea breath test confirmed eradication of Helicobacter pylori. Repeat colonoscopy showed no regression of the tumour. The patient received external beam radiation treatment. Subsequent positron emission tomography/CT scans demonstrated no evidence of viable tumour tissue and no regional or distant metastasis. Follow-up sigmoidoscopy with biopsy revealed no evidence of lymphoma.

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  • Competing interests None.

  • Patient consent Obtained.

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