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Unusual association of diseases/symptoms
Paraneoplastic hyperthyroidism
  1. Sibylle Kohler1,
  2. Oliver Tschopp1,
  3. Emanuel Jacky2,
  4. Christoph Schmid1
  1. 1Endocrinology Department, University Hospital Zurich, Zurich, Switzerland
  2. 2Oncology Department, University Hospital Zurich, Zurich, Switzerland
  1. Correspondence to Dr Sibylle Kohler, sibskohler{at}


The authors describe a 31-year-old male with a metastatic germ cell tumour and massively elevated human chorionic gonadotrophin (HCG) levels who presented with hyperthyroidism. As HCG is structurally closely related to thyroid stimulating hormone (TSH), it can activate the TSH receptor; grossly elevated levels may result in hyperthyroidism. After initiation of chemotherapy, HCG levels decreased and hyperthyroidism resolved.

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  • Competing interests None.

  • Patient consent Obtained.