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Unexpected outcome (positive or negative) including adverse drug reactions
Breathless on bortezomib
  1. Devaki O’Riordan1,
  2. John Houghton2,
  3. Roger Chisholm3,
  4. B Ronan O’Driscoll1
  1. 1Respiratory Medicine Department, MAHSC at Salford Royal NHS Foundation Trust, Manchester, UK
  2. 2Haematology Department, MAHSC at Salford Royal NHS Foundation Trust, Manchester, UK
  3. 3Radiology Department, MAHSC at Salford Royal NHS Foundation Trust, Manchester, UK
  1. Correspondence to Dr Devaki O’Riordan, devaki.o’riordan{at}srft.nhs.uk

Summary

The authors describe a case of episodic acute pneumonitis occurring after repeated doses of bortezomib, a drug being used increasingly to treat multiple myeloma. The delay in presentation each time with fever, dyspnoea, hypoxia and interstitial radiological changes contributed to under-recognition of this complication, which has so far been described in only a handful of patients, but the pattern seen may offer clues to pathogenesis and potential treatments. This case highlights the need for both physicians and patients consenting to bortezomib treatment to be more aware of this potentially fatal adverse effect.

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Footnotes

  • Competing interests None.

  • Patient consent Not obtained.

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