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Unusual association of diseases/symptoms
Severe hyponatraemia during sepsis and marijuana addiction
  1. Concetta Catalano,
  2. Sidy Seck,
  3. Giuseppe Enia
  1. Nephrology, Dialysis and Transplantation Unit, CNR-IBIM Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Ospedali Riuniti, Via Vallone Petrara, Reggio Calabria, Italy
  1. Correspondence to Dr Giuseppe Enia, enia1951{at}


The authors report a 29-year-old kidney transplant patient who presented, four episodes of severe hyponatraemia associated with sepsis from 2006 to 2010. He was a long-term user of marijuana. The association between severe recurrent hyponatraemia during sepsis and marijuana addiction might not be casual, since experimental data show that vasopressin release induced by sepsis is modulated by the endocannabinoid system.

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  • Competing interests None.

  • Patient consent Obtained.