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A 7-years-old boy was referred to our hospital because of a large left upper para-mediastinal mass at x-rays (figure 1A) with the suspicion of lymphoma. He had no respiratory symptoms, auscultation was normal. High-resolution CT showed a large consolidated mass (4 × 3.5 cm × 7.4 cm) in the left upper pulmonary lobe, of lung origin as two bronchial branches (figure 1B). At admission the boy was on full anti-tuberculosis (TBC) treatment. Two months earlier he had had a third episode of suppurative laterocervical adenitis, with histological finding of granulomas, isolation of Staphylococcus aureus from culture and a weak positive Mantoux. The boy had received BCG at birth. A careful history revealed three episodes of laterocervical adenitis, all characterised by S.aureus isolation, and two episodes of osteomyelitis. The first episode of osteomyelitis involved the second finger of the left hand, while the second episode the third right toe. Recurrence of staphyloccocal adenitis, histological granulomatous aspect, no response to TBC treatment, osteomyelitis of small bones of hands and feet, male sex were all suggestive of chronic granulomatous disease (CGD).1 Nitroblue-tetrazolium test confirmed CGD. Given this diagnosis, our first hypothesis was pulmonary Aspergillosis as Aspergillus is the most frequently isolated organism in CGD patients.2 3 Aspergillus fumigatus was isolated from the hypopharyngeal culture confirming the diagnosis. Voriconazole was started leading to volumetric reduction of the aspergilloma which was later removed surgically. Histological examination showed fungal hyphae in the context of the removed mass.
Our patient has undergone a successful bone marrow transplantation and he is now on no treatment. Diagnosis of pulmonary aspergillosis remains difficult in that clinical manifestations are not specific and radiologic findings can be suggestive but none are pathognomonic.4 However, it should be always suspected in case of a consolidated mass in a CGD patient.
Competing interests None.
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