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Unusual association of diseases/symptoms
A rare case of male breast ductal carcinoma in-situ associated with prolactinoma
  1. Chandike Maithri Mallawaarachchi1,
  2. Snezana Ivanova2,
  3. Alice Shorthouse2,
  4. Sami Shousha2,
  5. Dudley Sinnett2
  1. 1Department of Vascular Surgery, Hillingdon Hospital, Greater London, UK
  2. 2Department of Breast Surgery, Charing Cross Hospital, London, UK
  1. Correspondence to Chandike Maithri Mallawaarachchi, chandike{at}


A case of ductal carcinoma in-situ (DCIS) associated with prolactinoma in a male patient is described. A 56-year-old gentleman presented with lethargy and loss of libido. His prolactin at presentation was 3680 mU/l and an MRI scan of the head revealed a pituitary tumour suggestive of prolactinoma. Following 18 months of treatment with cabergoline, the prolactin level reduced to 914 mU/l. However, 3 years later he presented with blood stained nipple discharge, the cytology of which was negative for cancer. Ultrasound scan of his right breast revealed a single dilated mammary duct. Microdochectomy was performed. The histology revealed incompletely excised DCIS. There is increasing evidence of prolactinoma associated with breast cancer with or without DCIS in females. A review of the literature reveals only one previous case report of this association in males. This is the first case of pure DCIS preceded by prolactinoma in a male patient.

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  • Competing interests None.

  • Patient consent Obtained.

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