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Rare disease
Duodenal adenocarcinoma arising from a pyloric gland adenoma with a brief review of the literature
  1. T S Khor1,
  2. I Brown2,
  3. J Kattampallil3,
  4. I Yusoff4,
  5. M P Kumarasinghe5
  1. 1Department of Histopathology, PathWest, Fremantle Hospital, Fremantle, Australia
  2. 2Department of Histopathology, Sullivan Nicolaides Pathology, Taringa Australia
  3. 3Department of Histopathology, Western Diagnostic Pathology, Perth, Australia
  4. 4Department of Gastroenterology, Sir Charles Gairdner Hospital, Perth, Australia
  5. 5Department of Histopathology, PathWest, Queen Elizabeth II Medical Centre, Perth, Australia
  1. Correspondence to T S Khor, tzekhor{at}


Pyloric gland-type adenoma of the duodenum with documented malignant progression is rare. A case is presented of an 87-year-old man with bloating and nausea, who on investigation was found to have a polyp on the anteroinferior wall of the duodenal cap. Histologic examination of the polyp showed features of a pyloric gland adenoma (PGA) demonstrating the full spectrum of progression from low- to high-grade dysplasia and finally invasive adenocarcinoma. The carcinoma showed gastric-type differentiation highlighted by its mucin immunohistochemistry profile and was of advanced stage with lymph node metastasis. The literature on PGAs and the little documentations on progression to carcinoma in duodenal PGAs are reviewed.

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  • Competing interests None.

  • Patient consent Obtained.

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