Article Text

Novel treatment (new drug/intervention; established drug/procedure in new situation)
Zinc and vitamin A can minimise the severity of oral submucous fibrosis
  1. Richa Dhariwal1,
  2. Sanjit Mukherjee2,
  3. Sweta Pattanayak (Mohanty)1,
  4. Avirup Chakraborty2,
  5. Jay Gopal Ray1,2,
  6. Keya Chaudhuri2
  1. 1Dr R Ahmed Dental College & Hospital, Kolkata-700014, India, Oral and Maxillofacial Pathology, 114, Acharya Jagadish Chandra Bose Road, Kolkata, 700014, India
  2. 2Indian Institute of Chemical Biology, Molecular and Human Genetics, 4, Raja Sc Mullick Road, Kolkata, 700032, India
  1. Correspondence to Jay Gopal Ray, jaygopalray{at}


We report a case of a 24-year-old man who presented with a complaint of reduced mouth opening and a burning sensation. On examination, he was clinically diagnosed with oral submucous fibrosis (OSF). Following routine biopsy and histopathological confirmation of OSF, the patient was supplemented with zinc acetate along with vitamin A and was followed up for 4 months. Following treatment the patient reported increased mouth opening and a reduced burning sensation. Histopathologically re-epithelialisation was evident along with the appearance of normal rete pegs. The data for mouth opening, collagen content and epithelial thickness of six other cases similarly treated are also presented, showing a significant increase in mouth opening and epithelial thickness and decrease in collagen content. We propose the use of zinc acetate and vitamin A for the management of OSF.

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  • Competing interests: None.

  • Patient consent: Patient/guardian consent was obtained for publication.