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Novel treatment (new drug/intervention; established drug/procedure in new situation)
Successful response to intravenous immunoglobulin as rescue therapy in a patient with Hashimoto's encephalopathy
  1. Rodrigo Cornejo1,
  2. Pablo Venegas2,
  3. Daniela Goñi3,
  4. Alvaro Salas4,
  5. Carlos Romero5
  1. 1Medicine Department, Critical Care Unit, Clinical Hospital Universidad de Chile, Santiago, Región Metropolitana, Chile
  2. 2Neurology Department, Clinical Hospital Universidad de Chile, Santiago, Región Metropolitana, Chile
  3. 3Department of Internal Medicine, Universidad de Chile, Santiago, Región Metropolitana, Chile
  4. 4Radiology Department, Clinical Hospital Universidad de Chile, Santiago, Región Metropolitana, Chile
  5. 5Medicine Department, Intensive Care Unit, Clinical Hospital Universidad de Chile, Santiago, Región Metropolitana, Chile
  1. Correspondence to Rodrigo Cornejo, racornej{at}gmail.com

Summary

The authors describe the case of a 61-year-old woman who was admitted to our intensive care unit (ICU) due to impaired consciousness associated with generalised seizures. Her cerebrospinal fluid, electrolytes, acid-base analysis, and common laboratory and toxicology tests were normal. An MRI ruled out the presence of stroke or haemorrhage but showed severe leukoencephalopathy. Parkinson's disease, Creuzfeld–Jacob disease, vascular alterations, cancer, and rheumatological and metabolic diseases were evaluated and excluded. In view of her history of hypothyroidism despite adequate hormonal replacement and clinical behaviour, Hashimoto's encephalopathy was considered. Anti-thyroperoxidase levels were above 3000 IU/ml. The patient received 5 g of methylprednisolone followed by prednisone, but after a favourable initial response, returned to a comatose state. However, after administration of intravenous immunoglobulin (IVIG) 2 g/kg, the patient recovered with resolution of neurological symptoms and was discharged from the ICU 4 days after finishing IVIG treatment.

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Footnotes

  • Competing interests None.

  • Patient consent Obtained.

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