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Rare disease
Brain metastasis from medullary thyroid carcinoma
  1. P Börcek1,2,
  2. S L Asa1,2,
  3. F Gentili3,
  4. S Ezzat4,
  5. T-R Kiehl1,2
  1. 1Department of Pathology, Batman Regional State Hospital, Batman, Turkey
  2. 2Department of Pathology, University Health Network, Toronto, Ontario, Canada
  3. 3Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
  4. 4Department of Medicine, Division of Endocrinology and Metabolism, Mount Sinai Hospital and Princess Margaret Hospital, Toronto, Ontario, Canada
  1. Correspondence to Kiehl T-R, rasmus.kiehl{at}


The brain is an exceedingly rare site of metastasis in medullary thyroid carcinoma (MTC). A 50-year-old female who had a history of micro-MTC 11 years prior developed a cerebellar metastasis which was incidentally discovered. Imaging revealed a right cerebellar hemispheric mass with contrast enhancement on CT scans. Histopathologic exam demonstrated a metastatic tumour composed of nodules and sheets of large tumour cells with abundant cytoplasm. Immunohistochemistry confirmed the origin from a MTC. This case report highlights the unique features of an unusual metastatic brain tumour, which followed an indolent course for a long time despite multiple distant metastases.

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  • Competing interests None.

  • Patient consent Obtained.

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