Article Text

Rare disease
Wegener’s granulomatosis in pregnancy: a case report and review of the medical literature
  1. Vinodh Nanjanna Devakumar1,2,
  2. Madhura Castelino3,
  3. Shien-Ching Chow4,
  4. Lee-Suan Teh4
  1. 1
    The Royal Oldham Hospital, Rheumatology and Medicine, K Block, Rochdale Road, Oldham, OL1 2JH, UK
  2. 2
    Kendal Drive, Gatley, Cheadle, Cheshire SK84QJ, UK
  3. 3
    Royal Blackburn Hospital, Rheumatology, Rheumatology Department, Blackburn BB2 3HH, UK
  4. 4
    Royal Blackburn Hospital, Department of Rheumatology, Haslingden Road, Blackburn BB2 3HH, UK
  1. Correspondence to Madhura Castelino, castelinom{at}


A Caucasian woman in the third trimester of her sixth pregnancy was diagnosed with Wegener’s granulomatosis (WG) following investigation for recurrent ear infections and a persistent dry cough. Chest radiograph showed granulomatous lesions and the c-ANCA (antineutrophil cytoplasmic antibody) was strongly positive. She required pulsed methylprednisolone and cyclophosphamide followed by oral prednisolone and azathioprine to control the disease process during and after pregnancy. Neither the disease nor aggressive treatment adversely affected the pregnancy and she delivered a healthy baby girl by elective induction at 37 weeks. A review of the literature on Wegener’s granulomatosis in pregnancy is presented.

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  • Competing interests: None.

  • Patient consent: Patient/guardian consent was obtained for publication.