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Unexpected outcome (positive or negative) including adverse drug reactions
Spontaneous regression in advanced non-small cell lung cancer
  1. Adam Gladwish1,
  2. Katy Clarke2,
  3. Andrea Bezjak2
  1. 1University of Toronto, Toronto, Ontario, Canada
  2. 2Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
  1. Correspondence to Adam Gladwish, adam.gladwish{at}


Locally advanced lung cancer, if untreated, typically progresses although the rapidity of progression may vary. The authors report the case of an 84-year-old woman who presented with radiologically progressive, biopsy proven stage IIIB (T2N3) squamous cell carcinoma in the left lower lobe of the lung. Her disease was too advanced for curative treatment and in view of the lack of symptoms to palliate, she received no anticancer treatment. In follow-up, her tumour was noted to spontaneously regress in size on serial chest x-rays. Eight months after biopsy, restaging CT showed complete resolution of the enlarged biopsy proven mediastinal and hilar lymph nodes and significant regression of the primary tumour. She remains clinically well.

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  • Competing interests None.

  • Patient consent Obtained.

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