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Novel treatment (new drug/intervention; established drug/procedure in new situation)
Effect of Lactobacillus casei on Streptococcus bovis in faecal flora
  1. Atsuko Kawano1,
  2. Hideki Ishikawa2,
  3. Ikuko Akedo3,
  4. Tomiyo Nakamura4,
  5. Kazumasa Matsumoto5,
  6. Hiroo Takayama5,
  7. Akemi Imaoka5,
  8. Yoshinori Umesaki5,
  9. Ryuichiro Tanaka5,
  10. Toru Otani6,
  11. Toshiyuki Sakai2
  1. 1
    Osaka Medical College, Division of Preventive and Social Medicine, Department of Hygiene and Public Health, 2-7 Daigakutyo Takatsuki City Osaka, Takatsuki, 569-8686, Japan
  2. 2
    Kyoto Prefectural University of Medicine, Department of Molecular-Targeting Cancer Prevention, 2-17 Imahashi, 3-chome Tyuo-ku, Osaka City, Osaka, 541-0042, Japan
  3. 3
    Osaka Medical Center for Cancer and Cardiovascular Diseases, Gastroenterology, 1-3-3 Nakamichi Higashinari-ku, Osaka, 537-8511, Japan
  4. 4
    Osaka University, Pathology, School of Allied Health Science, Faculty of Medicine, 1-7 Yamada-oka, Suita, Osaka, 565-0871, Japan
  5. 5
    Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, 186-0011, Japan
  6. 6
    Otani clinic, 1-4-2-205 Nakamichi Higashinari-ku, Osaka, 537-0025, Japan
  1. Hideki Ishikawa, cancer{at}


Bacteraemia caused by Streptococcus bovis is often associated with colorectal tumours. Also, experimental studies have been proposed that S bovis acts as a promoter of tumours. We report the case of a man with colon adenoma who had a high proportion of S bovis in his faecal flora. He was treated with a Lactobacillus casei preparation (BLP) and the effect on the faecal flora was examined. L casei reduced the proportion of S bovis (from 43% down to 9%), and the effect continued after the administration of BLP was stopped. Our data indicate that BLP can repress the excessive colonisation of S bovis.

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  • Competing interests: None.

  • Patient consent: Patient/guardian consent was obtained for publication.

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