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Unusual association of diseases/symptoms
A 95-year-old woman with leucocytosis and eosinophilia: anaplastic carcinoma in an ectopic thyroid
  1. Einstein Francisco Camargos1,
  2. Marcela Basso Pandolfi1,
  3. Maria Alice V Toledo1,
  4. Juliana Lima Quintas1,
  5. Sebastião Moreira-Junior2,
  6. Ana Emília Borges de Azevedo3,
  7. Alexandre Cavalca Tavares3
  1. 1Geriatric Medical Centre, University Hospital, Brasilia University, Brasilia, Brazil
  2. 2Brasilia University, Brasilia, Brazil
  3. 3Medical Pathology Center, University Hospital, Brasilia University, Brasilia, Brazil
  1. Correspondence to Einstein Francisco Camargos, einstein{at}


A 95-year-old woman had been treated over the past 8 years for progressive dysphagia. When her condition worsened, blood tests revealed the presence of leucocytosis and eosinophilia in the absence of anaemia or thrombocytopenia. Within 11 days of diagnosis, the patient died of respiratory failure. Necropsy showed normal thyroid tissue and an absence of infectious disease. However, an upper mediastinal tumour was found and was histopathologically diagnosed as a neoplastic transformation of the ectopic thyroid. Only 1% of endothoracic goitres present as ectopic or autonomous goitre with no parenchymal or vascular connection to the thyroid gland. This case represents a very rare situation in which a leukemoid reaction and peripheral hypereosinophilia were observed as a manifestation of an anaplastic thyroid carcinoma in an ectopic mass.

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  • Competing interests None.

  • Patient consent Obtained.