Article Text

Rare disease
Pseudomembranous colitis in four patients with cystic fibrosis following lung transplantation
  1. B Yates,
  2. D M Murphy,
  3. A J Fisher,
  4. F K Gould,
  5. J L Lordan,
  6. J H Dark,
  7. P A Corris
  1. Institute of Cellular Medicine, University of Newcastle and The Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK
  1. Paul A Corris, paul.Corris{at}


In the present study, 4 patients with cystic fibrosis undergoing lung transplantation (from a total of 137) who developed fulminant pseudomembranous colitis are described. Initial presentation was variable and the mortality rate was 50% despite urgent colectomy. In one case the presenting abdominal distension was thought to be due to meconium ileus equivalent. It is concluded that Clostridium difficile colitis may be a difficult diagnosis in patients with cystic fibrosis and follows a fulminant course after lung transplantation.

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  • Competing interests: none.