Article Text

Rare disease
Postprandial hyperinsulinaemic hypoglycaemia and type 1 diabetes mellitus
  1. Myra Poon,
  2. Khalid Hussain
  1. London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, London, UK
  1. K Hussain, K.Hussain{at}


A patient with severe postprandial hyperinsulinaemic hypoglycaemia (PPHH) for 4 years developed type 1 diabetes mellitus. She had no insulin or insulin receptor antibodies but was positive for islet cell and glutamic acid decarboxylase (GAD) antibodies. PPHH prior to the onset of type 1 diabetes mellitus has not been previously described and may be a prodrome of type 1 diabetes mellitus.

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  • Competing interests: none.