You are here

Article Text

Article menu
Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
Keratoconus associated with CSNB1
  1. Dan Nguyen1,
  2. Chris Hemmerdinger2,
  3. Richard Hagan3,
  4. Malcolm Brown3,
  5. Say Aun Quah2,
  6. Stephen Kaye2
  1. 1
    Bristol Eye Hospital, Lower Maudlin Street, Bristol, BS1 2LX, UK
  2. 2
    St Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, L7 8XP, UK
  3. 3
    Department of Clinical Engineering, Royal Liverpool University Hospital, Liverpool, L7 8XP, UK
  1. danqbnguyen{at}hotmail.com

Summary

A 35-year-old man with best corrected visual acuities of −18.00/+10.00×180 (6/60) OD and −10.00/+8.00×5 (6/36) OS. Bilateral steep central corneal thinning, paracentral ectasia and Vogts striae were present; normal fundi. Corneal topography disclosed 7.4 dioptres of irregular astigmatism in the central 3 mm with thinning (335 μm). Electroretinography (ERG) showed no response. There were no medical or environmental influences for his keratoconus. Occurrence of keratoconus and CSNB in the patient may represent a chance association, but keratoconus has not been previously linked with CSNB1 either as a chance or true association though both show genetic predisposition.

View Full Text

http://dx.doi.org/10.1136/bcr.09.2008.0877

Statistics from Altmetric.com

    View Full Text

    Footnotes

    • Competing interests: None.

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Copyright information:

    2009 BMJ Publishing Group Ltd