You are here

Article Text

Article menu
Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
Parkinson’s disease with Onuf’s nucleus involvement mimicking multiple system atrophy
  1. Sean Stephen O’Sullivan1,2,
  2. Luke A Massey1,
  3. David R Williams1,3,
  4. Tamas Revesz1,
  5. Andrew Lees1,4,
  6. Janice Holton5
  1. 1
    Queen Square Brain Bank, Department of Molecular Neuroscience, Institute of Neurology, University College London, London, WC1N 1PJ, UK
  2. 2
    University College London, Reta Lila Weston Institute, 1 Wakefield Street, London, WC1N 1PJ, UK
  3. 3
    Faculty of Medicine (Neurosciences), Monash University (Alfred Hospital Campus), Melbourne, Victoria, Australia
  4. 4
    University College London, Reta Lila Weston Institute, 1 Wakefield Street, London, N7 6EZ, UK
  5. 5
    Institute of Neurology, Molecular Neuroscience, Queen Square, London, WC1N 3BG, UK
  1. alees{at}ion.ucl.ac.uk

Summary

Urinary frequency, urgency and nocturia are common complaints in Parkinson’s disease (PD). The hypothesis most widely proposed to explain neurogenic bladder symptoms in PD is that cell loss in the substantia nigra may cause detrusor hyperactivity due to a loss in the D1 receptor-mediated tonic inhibition of the micturition reflex, although other causes including anti-parkinsonian medication cortical effects have been considered.1 We present the clinical and pathological findings of a patient with parkinsonism who presented with prominent dysautonomia and a poor response to dopaminergic medications and was considered to have possible multiple system atrophy parkinsonism (MSA-P). Pathological examination revealed that the patient had PD with α-synuclein pathology in the Onuf’s nucleus (ON).

https://doi.org/10.1136/bcr.08.2008.0774

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Competing interests: None.