Article Text

Unusual presentation of more common disease/injury
The surgical management of pancreaticoduodenal tumours in multiple endocrine neoplasia type 1
  1. Sri G Thrumurthy,
  2. Ravindra S Date,
  3. Muntzer M Mughal,
  4. Kishore G Pursnani,
  5. Jeremy B Ward
  1. Lancashire Teaching Hospitals NHS Foundation Trust, Surgery, Preston Road, Chorley PR7 1PP, UK
  1. Sri G Thrumurthy, sri.thrumurthy{at}


A 48-year-old man was admitted under the care of urologists with acute renal failure and septicaemia secondary to pyelonephritis. Upon investigation, he was found to have renal stone disease secondary to a parathyroid adenoma. Further tests revealed high pituitary hormone and gastrin values, confirming the diagnosis of multiple endocrine neoplasia type 1 (MEN 1) and Zollinger–Ellison syndrome. Soon after this he experienced a series of renal complications due to his renal stone disease and multiple complications of his gastrinoma, including two gastrointestinal perforations and three episodes of significant upper gastrointestinal bleeds (two of which required laparotomies), and a full length oesophageal stricture—all within the span of 9 months. His complications were managed appropriately and the oesophageal stricture was treated with a full length metallic stent. He was discharged home in a reasonably good condition with normal swallowing, but unfortunately died of aspiration pneumonia 3 weeks later.

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  • Competing interests: none.