Article Text

Novel diagnostic procedure
Contribution of the 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography to the diagnosis of primary osseous Hodgkin lymphoma
  1. Florence Breibach1,
  2. Anne Julian2,
  3. Camille Laurent1,
  4. Eric Anglade3,
  5. Arnaud Constantin4,
  6. Nicolas Sans5,
  7. Jean-Louis Tricoire6,
  8. Pierre Brousset1,
  9. Marie-Bernadette Delisle7,
  10. Anne Gomez-Brouchet7
  1. 1
    Centre Hospitalier Universitaire de Purpan, Anatomie et Cytologie Pathologiques, Place du Docteur Baylac, Toulouse, 31059, France
  2. 2
    Centre Hospitalier Universitaire de Purpan, Médecine Nucléaire, Place du Docteur Baylac, TSA 40031, Toulouse Cedex 9, 31059, France
  3. 3
    Centre Hospitalier Universitaire de Purpan TSA 40031, Radiologie, Place du Docteur Baylac, Toulouse Cedex9, 31059, France
  4. 4
    Centre Hospitalier Universitaire de Rangueil-Larrey, TSA 50032, Rhumatologie, 24, chemin Pouvourville, Toulouse Cedex 9, 31059, France
  5. 5
    Centre Hospitalier Universitaire Purpan, Radiology, Place du Docteur Baylac TSA 40031, Toulouse cedex 9, 31059, France
  6. 6
    Centre Hospitalier Universitaire Purpan, Chirurgie Orthopédique, Place du Docteur Baylac TSA 40031, Toulouse, 31059, France
  7. 7
    Centre Hospitalier Universitaire Rangueil, Anatomie et Cytologie Pathologiques, 1, Avenue du Pr Jean Pouhles, TSA 50032, Toulouse cedex 9, 31059, France
  1. Anne Gomez-Brouchet, brouchet.anne{at}


Hodgkin lymphoma typically presents as a nodal lesion and infrequently involves extra nodal sites. Although cases of primary extra-nodal Hodgkin lymphoma have been reported previously, the reality of the primitive nature of the disease was difficult to authenticate with traditional high resolution imaging techniques, such as computed tomography or magnetic resonance imaging, because they cannot evaluate the spread of the disease throughout the whole body. We report here a case of primary osseous Hodgkin lymphoma, regarded as stage I extranodal IE thanks to the important contribution of a new imaging technique, the 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography/ computed tomography (18F-FDG-PET/CT). PET enables systemic Hodgkin lymphoma with secondary bone invasion to be distinguished from primitive osseous Hodgkin lymphoma. This technique is highly specific in demonstrating the isolated osseous localisation of the tumour and should be recommended in all patients with putative osseous lymphoma.

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  • Competing interests: none.

  • Patient consent: Patient/guardian consent was obtained for publication