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Reminder of important clinical lesson
A case report of a salivary amylase secreting plasmacytoma in a patient with multiple myeloma
  1. Serena L Harborne1,
  2. Rachael Curley2,
  3. David W Bullimore3,
  4. Dominic Chan-lam1,
  5. Jean-Pierre Ng1,
  6. Philip T McAndrew4
  1. 1
    Barnsley Hospital Foundation Trust, Haematology, Gawber Road, Barnsley, S75 2EP, UK
  2. 2
    Barnsley Hospital Foundation Trust, General Medicine, Gawber Road, Barnsley, S75 2EP, UK
  3. 3
    Barnsley Hospital Foundation Trust, Gastroenterology, Gawber Road, Barnsley, S75 2EP, UK
  4. 4
    Barnsley Hospital Foundation Trust, Radiology, Gawber Road, Barnsley, S75 2EP, UK
  1. Serena L Harborne, serenal999{at}


A 70-year-old lady with a past medical history of light chain myeloma, chronic renal failure and a left breast plasmacytoma treated with radiotherapy was admitted for drainage of a subsequent left pleural effusion. She was given high dose steroids for her myeloma, following which she developed abdominal pain suspicious of pancreatitis. Results revealed a raised serum amylase of 5117, a modified Glasgow score of 3 and normal calcium levels. The working diagnosis was drug-induced pancreatitis and steroids were stopped. She remained well and her abdominal pain settled, but amylase remained markedly raised despite no findings of pancreatic pathology. A subsequent isoenzyme test on the amylase found it to be salivary amylase secreted from the plasmacytoma. The patient had her steroid therapy restarted and was allowed to be discharged from hospital.

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  • Competing interests: none.

  • Patient consent: Patient/guardian consent was obtained for publication.

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