Article Text

Rare disease
Early gastric cancer in Menetrier’s disease
  1. Jose Maria Remes-Troche1,
  2. Juan Carlos Zapata-Colindres2,
  3. Ivethe Starkman3,
  4. Jazmin De Anda4,
  5. Julian Arista-Nasr4,
  6. Miguel Angel Valdovinos-Diaz2
  1. 1
    Instituto de Investigaciones Medico Biologicas, Laboratorio de Fisiologia Digestiva y Motilidad. Iturbide SN, Col. Flores Magon, Veracruz 91400, Mexico
  2. 2
    Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Colonia Seccion XVI, 14000, Mexico
  3. 3
    Universidad Autonoma de Honduras, Honduras, Tegucigalpa, 13456, Honduras
  4. 4
    Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Colonia Seccion XVI, 14000, Mexico
  1. J M Remes-Troche, jose.remes.troche{at}gmail.com

Summary

Uncommon conditions such as pernicious anaemia and hypertrophic gastropathies have been considered as risk factors for gastric cancer; however, the exact increase in risk is unknown. Menetrier’s disease is a rare hyperproliferative disorder of the stomach caused by an overexpression of tumour growth factor α, a ligand for the tyrokinase epidermal growth factor receptor, resulting in a selective expansion of surface mucous cells in the body and fundus of the stomach. There have been nearly 200 cases of Menetrier’s disease reported in the literature yet less than 15 have been associated with gastric adenocarcinoma. Here, we report an early stage gastric adenocarcinoma detected incidentally in a patient recently diagnosed with Menetrier’s disease.

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Footnotes

  • Competing interests: none.

  • Patient consent: Patient/guardian consent was obtained for publication.

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