Article Text

Unexpected outcome (positive or negative) including adverse drug reactions
Capecitabine (oral 5-fluorouracil pro-drug) treatment for colorectal carcinoma causing ischaemic chest pain
  1. Trevor Aidan McGoldrick1,2,
  2. Duncan Jodrell3,
  3. Sally Clive2
  1. 1
    University of Edinburgh, Clinical Pharmacology, Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
  2. 2
    Edinburgh Cancer Centre, Medical Oncology, Western General Hospital, Crew Road South, Edinburgh EH4 2XU, UK
  3. 3
    University of Cambridge, Oncology, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK
  1. tmcgoldrick{at}


We present a case of cardiac ischaemia associated with capecitabine chemotherapy. An elderly female receiving capecitabine chemotherapy developed acute onset severe anterior chest pain associated with ischaemic changes on ECG. The pain and ECG changes failed to respond to thrombolysis and she proceeded to coronary angiogram and stenting of a thrombosed right coronary vessel. She inadvertently recommenced her capecitabine with a further episode of chest pain. On cessation of capecitabine she had no further episodes of chest pain.

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  • Competing interests: none.

  • Patient consent: Patient/guardian consent was obtained for publication.