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Unusual presentation of more common disease/injury
Extensively drug resistant tuberculosis in a 7-year-old child with interferon-γ and interleukin-12 deficiency
  1. Ketan Kulkarni,
  2. Meenu Singh,
  3. Pooja Soneja,
  4. Joseph Mathew,
  5. Ram Kumar Marwaha
  1. Department of Pediatrics, Advanced Pediatrics Center, PGIMER, Chandigarh, 160012, India
  1. meenusingh4{at}rediffmail.com

Summary

Defects in interferon-γ axis have been shown to be associated with disseminated mycobacterial disease. A case of a previously healthy HIV seronegative child with disseminated extensively drug resistant Mycobacterium tuberculosis infection presenting as splenic abscesses with lymphadenopathy and progressing to disseminated tuberculosis with absent interferon-γ and interleukin-12 production is reported here.

https://doi.org/10.1136/bcr.06.2008.0293

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    Footnotes

    • Competing interests: none.

    • Patient consent: Patient/guardian consent was obtained for publication